Nrf2 Protects Against Joint Degeneration

Oxidative stress is high in rheumatoid arthritis suffers. In this study (Antioxidants & Redox Signaling 15(4)), Nrf2, a master regulator of redox balance, was examined in an animal model of rheumatoid arthritis. Nrf2 deficiency accelerated the incidence of arthritis, and animals showed widespread disease affecting both front and hind paws. So the Nrf2 deficient mice inflammatory … More Nrf2 Protects Against Joint Degeneration