Nrf2 Protects Against Joint Degeneration

Oxidative stress is high in rheumatoid arthritis suffers. In this study (Antioxidants & Redox Signaling 15(4)), Nrf2, a master regulator of redox balance, was examined in an animal model of rheumatoid arthritis. Nrf2 deficiency accelerated the incidence of arthritis, and animals showed widespread disease affecting both front and hind paws. So the Nrf2 deficient mice inflammatory … More Nrf2 Protects Against Joint Degeneration

Sugar Rust = A.G.E.

Simple carbohydrates (sugars) tend to be very reactive and stick to lots of stuff including all of your cellular structures. Once the sugar reacts with a molecule, these modified proteins and fats are termed advanced glycation end-products (or AGE). AGE are toxic by-products of metabolism, but are also also acquired from high-temperature processed foods. … More Sugar Rust = A.G.E.